I tested Fallout 4 a few years ago and found that there were some serious mouse and audio issues. Tried a bunch of workarounds and gave up. Test again later and same problems. Even the older Fallout games had some problems but could be resolved with a few hacks and overrides.

Today Fallout 4 runs great in Proton because of the DXVK efforts and faudio compatibility. I was able to run Fallout 4 with the following "launch options":

Code:

WINEDLLOVERRIDES="xaudio2_7=n,b" PULSE_LATENCY_MSEC=90 %command%

Fallout 4 plays almost perfectly on my GeForce GX 1060 with everything set to Ultra! There area few graphical bugs with loading textures/decals, but its rarely noticeable.



Specs:
Mint 19.3 64-bit
GeForce GTX 1060
Nvidia 440.100
Proton 5.0-9